The efficacy of repetitive transcranial magnetic stimulation (rTMS) for young individuals with high-level perceived stress: study protocol for a randomized sham-controlled trial

Abstract Background High level of perceived stress may result in negative effects both psychologically and physically on individuals predispose onset mental disorders such as depression, anxiety, posttraumatic disorder. However, there is no suitable intervention for it. Repetitive transcranial magnetic stimulation (rTMS) studies have shown its therapeutic efficacy treatment resistant patients with stress-related disorders. Here we describe an exploratory study protocol to investigate the effect high stress. Method This a single blinded, randomized sham-controlled trial, targeting at young healthy adults aging from 18 24 years old. Forty eligible volunteers will be recruited randomly divided into active sham rTMS group. All subjects take set neuropsychological biological assessments MRI scanning before right after intervention. During interventional period, 12-session stimulations performed 4 weeks three sessions per week. The primary outcome detect difference Chinese 14-item scales between groups Secondary outcomes examine differences other affective measurements, cortisol, MRI-derived neural functional measures two Discussion trial aims Positive or findings any would further our understanding impact. If effective, it provide evidence new Trial registration Clinical Registry ( ChiCTR1900027662 ). Registered 23 November 2019. And all items WHO Data can found within protocol.